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For the hole, just install a plumbing vent over it. Use putty tape on the bottom of the mounting flange and after screwing it down seal it with a lap sealant like Pro Flex ovedr the screw heads and edge of vent to the roof.
Mike, RVIA & RVSA Certified Master RV Technician
Amy, Dr. Assistant - Roxie & Mei Ling, four legs each
2000 Gulf Stream Scenic Cruiser 450 hp & 1330# torque
06 Saturn Vue, 06 Chevy Z71 4x4 & 2014 Corvette Z51 M7