Current self driving cars are already proven to be safer than human drivers.
From Google most recent statistic on their self driving fleet:
Over the 6 years since we started the project, we’ve been involved in 11 minor accidents (light damage, no injuries) during those 1.7 million miles of autonomous and manual driving with our safety drivers behind the wheel, and not once was the self-driving car the cause of the accident.
That is city driving, a much harder problem than what we are talking about here which is basically distance keeping cruise control along with lane keeping assist with ability to actually steer. These are already well proven systems you can get in cars today that react faster than any human and never get tired.
Remember that freightliner is licensed in Nevada and driving real roads already. It will completely change the trucking industry.
Motorhomes will take longer to get it manly due to the custom chassis and the sluggish pace of RV manufacturers to move forward. Remember though some manufacturers have offered the Vorad distance keeping cruise for a while on high end coaches.