A few years ago I motorcycled to Alaska with two friends. One wanted to pan for gold, the other wanted to stand on a glacier, and I wanted to go to the Arctic Circle. Their objective was easily accomplished while motorcycling. However, using our better judgement, we rented a car in Fairbanks and drove to the Arctic Circle, 66.5 degrees latitude, took a picture, and headed back south. As an aside, the car rental company expressly stated that we were not covered to travel the "haul road". As it turned out, we did have a flat on the way and had to buy a new tire before returning the car.
Needless to say, it can be done on a motorcycle or in an RV, however, the road is not your friend - it is the lifeline of the big rigs that make their money hauling stuff. Most of them do not give you a "courtesy pass" (i.e. slow down so the gravel doesn't splatter you) in either direction. The traffic is not so heavy now-a-days since the oil boom has slowed to a trickle, but there is still enough traffic to make a person nervous every time one of those behemoths comes into view.
If you are really serious about making the trip, I would suggest taking your toad and a good spare tire (or two). A couple other options would be to rent a car or take a tour bus.
2005 Fleetwood Excursion 39L, 350 Cat, Allison 3000, 1991 Honda Accord EX