The short answer is yes - I know some Canadians who have done so, both new and used. From what they have said, it was not a big deal. Most US built vehicles will meet Canadian standards.
If you deal with a US dealer near the border, they probably already have some experience in the paperwork for export to Canada. There are also firms that specialize in handling the details of import/export. I don't know how expensive they are.
Check with your provincial motor vehicle office - they should be able to tell you the procedure for importing a vehicle. You can also get information from the Canadian Registrar of Imported Vehicles web site - see http://www.riv.ca/
2004 American Tradition; 2014 Buick LaCRosse
Homebase in the Ocala Nat'l Forest near Ocala, FL