Simple answer is, yes they will cause the tire to be out of balance. But will you feel it, not likely. On a car you might, but not in the motorhome. Will there be any long term problems, most likely no. But out of balance is out of balance. I suggest using the balancing powders or beads in the tires. I suggest using enough of the powder or beads to correct up to 8 or 10 oz. of out of balance. If you are not familiar with the powders or beads, type balancing beads in any search engine and I'm sure you will get several hits. Talk to your tire dealer they can tell you about the powders and beads. Both can be installed without removing the tires. Many large commercial fleets use these in the truck tires.
2000 Itasca 35U