I disconnected my toad/dolly one time last year when I was changing the MH's hitch ball receiver. I needed to lower the height of the ball on the MH.
If you do this, block the toad tires or use the parking brake to keep the toad from rolling. Unhooking would be fairly easy. hooking back up will require some skill and patience to line up the hitch with the ball.
Don't forget to release the parking brake when your hooked back up.
Other than that, I don't see any problems.