It more depends on where the thermostats get their info. Our front AC uses the front thermostat installed in the front of the hallway, the sensor not very representative of the actual temp in the front of the coach, so I installed a remote thermistor just behind the copilot's seat to more realistically read the temp in the front. It was easy to do, there is a plug available at the inside of the AC unit that the thermistor plugs into and then I ran the wire through the duct, and finally to the spot where I mounted it. Our middle AC gets its temp reading from inside the toilet compartment, a great spot for our middle zone of heat, makes for a cozy cubicle, but not so hot for AC. We just accept the temp setting to be higher for comfortable AC, and we leave the door ajar when cooling. Then our bedroom thermostat input is from a thermistor that is on a bulkhead near the passenger side window, also not the best for AC, so we pull down a shade in that window to keep the sun off if the awning isn't down. Also as the sun moves around the coach, obviously the heating impact will change each individual AC's effectiveness. So with some experimentation we are comfortable.
2007 Navigator, 45' Series 60
Full-Timing since 2004