Can it be done ? Probably
Would it be easier and quicker with the rad and CAC out of the way ? Most likely.
Having done the water pump on my 3126B with side rad , I can imagine doing it with a rad , limiting access , but that's all I'd want to do ; imagine .
99DSDP 3884, Freightliner, XC, CAT 3126B, 300 HP /ALLISON 3060
2000 Caravan toad, Remco & Blue Ox.