For whatever reason, Freightliner finds it necessary to BURY the air dryer up in the frame rails. I'm sure it's very accessible and looks great to them on a bare chassis, but once you put a coach body on, it's almost impossible to access.
On my 2014 Dutch Star, they installed the air dryer on the frame rail near the duals, but with the coach body on, you couldn't remove to the cover to access the filter.
I found that it was easier, not really a good word for it, but easier to remove the entire assembly and do the filter replacement on the workbench.
I've been servicing my own vehicles for 45 years and this was one of the hardest jobs I've ever encountered (at least on my chassis). You need 4' arms to reach the darn thing. I asked my local Freightliner shop how much they would charge. They wanted $400.00, just in labor.
I checked my new 2019 coach, bad news.....they still put it in the same spot. Good news....for 2109, they went with a Wabco spin on. Hopefully, they left enugh room to spin it off.