Had the same problem. After running 1,650 miles without a problem, my engine kept losing prime and would not start. Long story short, the big fuel/water separator was leaking. Freightliner fixed it by removing the fuel/water separator, cleaning all the gaskets and connections and reinstalling it.
As noted, starter fluid should not be used.
2014 American Eagle 45T
DD 13, 500 HP
Pulling a Honda CRV