In that size, I'd strongly recommend the Toyo M144. Without looking up current prices, I'd say the M144 could be around $250 or more per tire less expensive than a comparable tire from Michelin, Continental, Goodyear, etc.
The M144 is a popular tire to use on a motorhome.
I seldom recommend this particular tire but I hear the Falken RI151 (description from their webpage go
HERE) is a relatively new tire where I now notice that some in the trucking industry are discussing it as being a very good tire that represents an exceptional value. I notice it comes in the 295/80R-22.5 size and for a very good price depending on availability.
The reason I mention the Falken brand is that they are made by Sumitomo which is one of my favorite brands along with Toyo and Yokohama ...all Japan-based companies. I believe I read somewhere that the Falken RI151 might be manufactured at the Sumitomo plant in Tonawanda NY outside of Buffalo. I'm not sure of that, however. But we know that many of the Sumitomo commercial truck tires are made at that plant and also some of the Falken passenger car tires are also manufactured there.
So the Falken RI151 may be also one to consider if its available where you shop for tires.
ETA: So just for comparison purposes, I'll randomly use a site called "World of Tires" (I've never purchased there but just using them so you can get an idea of the general price comparison between brands ...either shopping around or negotiating with your favorite local commercial tire dealer may or may not produce better prices):
Toyo M144 -- $513.04
Falken RI151 -- $481.98
Michelin XZA2 Energy -- $774.00
Goodyear G670 -- $883.10
Continental HSR2 SA -- $767.13