I travel the route often and you’ll find it ok. Bypass Hattiesburg, via us98W to I59N, and then back on US-49 (a gps usually gives that route).
There are lights, but the main problem at this time is the hwy 49 road construction, as you get near Jackson (Florence and Richland). The road is very rough through there.
David White '05 Monaco Windsor
'16 GMC Canyon 4x4
Madison, MS. Retired