46 is an easy road and it's worth the drive. Until they fix US 1 I'd turn the other way, base out of Morro Bay which is a gorgeous little town. One of my favorite kickin little Cali towns, and Cali has some *really* cool little towns. I miss it!
We stayed at Bay Pines which is OK I guess. Morro Dunes is in a great location if you brought your bikes, also there are a couple of teeny places off of Monterey Ave which are also well located. Run down to the docks and get some seafood, check out the sea otters, if you can stand that much cuteness in one package. Renting a kayak is a great way to spend a day and is highly recommended.
Take the toad back up 46 to check out wineries, Justin is *to die for* but you'll never get your rig back up in there. Then run up to Nacimiento-Fergusson road, loop back down to the PCH and follow that south, check out the elephant seals and zebras in San Simeon. Should have that part of the PCH to yourself because of the closure. Get dinner at the Sea Chest, the calamari steak is exquisite. All of this is great in the toad (even better by motorcycle) but don't even think about taking the rig down Nacimiento-Fergusson road. Which generally goes to show, just because you *can* take an RV somewhere doesn't mean that's the best way to get there
Same generally applies to the run from Monterey to Big Sur, I mean it's doable. Check the wind forecast, it can get brutal. Otherwise it's not a particularly technical drive, it's just that there are so many little places to pull over (and turn around) if you're in a car. Not so much in an RV. Monterey is a fantastic town, and likewise a fine home base for exploring.