I live off US-171, and have not been over as far east as US-165 since the storm, though I can tell you that most places in town have power back, with more getting power back every day. Water levels around here seem to be falling, though there are still downed trees on the shoulder of highways, etc.
I assume the conditions on US165 are a bit worse given its closer proximity to the eye, but overall from what I see in the area, I would not be too concerned, though I would certainly want to drive in the daytime. primarily due to the random downed tree or other debris on the shoulder / roadway. Also some traffic light signals, stop signs, and highway signs may be down.
2002 Safari Trek 2830 on P32 Chassis with 8.1L