You'll have Wolf Creek Pass (11,800') and North La Veta Pass (9,400') to surmount. We did that route in March 2020 in our Open Road (also F53) and pulling our toad. Both ascents are very doable, just take your time. It won't be a fast climb, but your rig is fully capable. On the downhills, especially down from the summit on Wolf Creek, you'll need to have your speed dialed down from the get go, using tow/haul to get you to a lower gear. It's a long 5%/6% descent. If you let your speed climb, you'll have to hit your brakes hard to get it back down. Better to have it under control from the start. North La Veta Pass will be similar, but not quite as rigorous as Wolf Creek.
Also, I suggest you get a copy of the Mountain West Directory so you can have details of these passes at your fingertips. RVTW is a great planning tool, but the Directory is what you want for the details. Safe travels.
Mike and Cindy
2016 Tiffin Allegro Open Road 34PA
2018 Chevy Malibu