Living in Asheville, that would be a good scenic route in my mind. It doesn't snow that much here in December and it is easy to avoid. That being said, I did get caught by an unusual December snow storm in Winston-Salem a couple of years ago. I-40 was a long linear parking lot. Ended up spending a night with my niece in Clemmons.
We like to travel the secondary roads in lieu of interstates when we can. Recently ran US 441 from Dillsboro, NC to below Lake City, FL. Enjoyed that drive much more than being on the interstates.
Zeb and Teena
2005 Mandalay, 2013 Ford Edge