After getting past Chicago, my favorite route would be I-65 & I-265 past Louisville, I-64 to Lexington, I-75 to Knoxville, I-40 to Asheville, I-26 to Columbia, I-20 & US-501 to Myrtle Beach. No reason to go through Atlanta unless you just want to see it and the heavy traffic.
Larry, Beverly & Pat
Pups - Romeo, Teddy Bear, Frankie
2013 Thor Tuscany, 45', Freightliner chassis, Cummins ISL10, towing a Buick Enclave