I've been on US280 from Montgomery, AL, through Columbus, GA and on to Albany, GA and then 82 to Tifton. It is mostly all 4 lane and nice roads. A few towns but no big deal. We'll be running 82/280 from Tifton again this weekend on our way to Columbus, GA. Just obey the speed limit.
A nice stop to stretch your legs in Weston, GA at Merit Pecan. Nice, friendly country store with clean restrooms and the usual gas station "stuff". My wife won't let me pass it by and always loads up on peans for cooking - so naturally I'm glad to accommodate the stop.
I don't think 82 is 4 lane between Montgomery, AL and Albany, GA.