Absolutely beautiful road. One of my favorites on a motorcycle - rode the southern half every summer in the 70s. The southern end in Marin can be narrow with tight turns, no shoulder at the guard rail, and rock cliffs on the inside curves. Not unusual for cars to come around the corners on or over the line. If you Google Map it, it's the section near Mt Tam/Muir Woods. You can avoid that section by going inland at Olema or Pt Reyes and reconnect with 101 in San Rafael (My old home town) :^)
The rest of it should be doable in a big rig. There may a be a few places where you have to take a curve slow, and time it so you can use a little bit of the other lane. Not many places like that though.
Tom M. 1998 Safari Serengeti 3706,
300HP Cat 3126 Allison 3060, 600 watts of Solar.
Fisher and Paykel Residential refrigerator