Being a Florida "cracker" and having traveled to and through Jacksonville frequently I agree with advising you to take 301. I would suggest you stay on 301 to State Hwy 326. 326 is about 5.5 miles South of the 441/301 split. You'll only be on 326 for maybe 5 miles to I-75. We go that route when we travel to Tampa area. Just watch you speed carefully through towns. When they say "speed limit" they really mean LIMIT. The small towns of Lawtey and Waldo are especially revenue huungry.
'02 Ultimate Advantage 40J Spartan MM - Cummins ISC
2013 Jeep Rubicon JK Unlimited