I really doubt that just driving over the passes would affect you. You will be gradually climbing and then descending. You, most likely, will not be staying at that elevation. I wouldn't be concerned about it.
Hwy 50 is the best route - 396 miles
If staying at those elevations then do so gradually.... perhaps at 6,000' then 8,000'.
People drive the passes all the time and I doubt they stop and stay at places to get acclimated, especially if driving an interstate.
Gunnison is 7700' EL
Then the climb to the pass at 11,300' El
Then the descent to Salida 7100' EL
It will only take you a short time to climb the pass.
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Full-timed for 16 Years . . .
Traveled 8 yr in a 2004 Newmar Dutch Star 40' Diesel
& 8 yr in a 33' Travel Supreme 5th wheel
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