It's a nice trip. (We live in northern NV so we're biased)
No traffic (at least between Winnemucca and Lakeview OR, and as I recall, one curvy section I think about 5 miles long with some 7-8% grade. Last I heard there was fuel at Denio Junction, but check beforehand if that's an issue.
The scenery is some of the best in the Great Basin, and there are tons of critters out there to watch out for.
I found this video on You Tube, of a trip starting at Denio Junction and heading westbound: