We have gone both ways (W.V. / VA vs. KY/ TN) from Western PA to Tampa and home.
The KY/TN route is an easier drive on you and your equipment, and you get slightly better gas mileage (.2-.3 mpg overall), but it is approximately 2 hours longer of a drive, and about 100 miles further.
If you have some time to spare and $25-$50.00 extra for fuel/gas for the return is not to big a concern, go the western route and enjoy a few nights at Natural Bridge State Park or Mammoth Cave National Park, or one of the distillery tours.
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