About 15 years ago, I used US-250 from Huttonsville, WV to Staunton, VA towing just a pop-up. You'd wind your way up one side of the mountain and then wind your way back down. At the bottom, there would be a small town with one traffic light. This pattern repeated itself a number of times. After about the second cycle, the "deja vu" feeling made me think that I was on a never ending trip. It's even worse if you happen to come upon a loaded coal truck or other slow moving vehicle along the way.
I don't know whether anything's improved on this stretch of road in the 15 years since I used it, but by looking at the maps, I'd be inclined to say it hasn't.
All I can say is if you elect to use this road, be very careful and alert.
2009 GMC Sierra 2500HD | Crew Cab | Standard Box | 4WD | Duramax/Allison
2000 Jayco Eagle 266 | FBS | TT
1986 Coleman Laramie pop-up -- Still in the family!!!