Yeah, by all means take that route, it's beauiful. We do it in our 42 pulling our Jeep. Scenery is great and the uphill grade is gradual and very, very scenic. One lane almost the whole way and you'll question your decision a couple of times but stay with it. Watch the road signs and your map though to be sure you stay on route. We go up 390 to 90 however to take the Lewiston / Queenston entry into Canada so I can't coment past there. Very nice drive for us though. By the way, if you're using the Peace Bridge to come to Canada you might want to consider 190 to the bridge(s) I mentioned. You cross Grand Island and the Niagara Gorge into Canada .... breathtaking.
Tony & Yolanda / Katie & Spencer (the Doodles)
2011 Fleetwood Revolution 42W (450/1250)
2008 Jeep Grand Cherokee (Diesel) behind