First,
Tread separation in and of itself has nothing to do with tire wear. There are any number of tires under 5th wheels that have proven themselves as being exceptionally prone to this problem, especially with age, underinflation and/or overloading. What brand/size tires are failing?
Are you seeing any tire wear that would be indicative of tire alignment/axle problems? If so, can you provide photos or description?
Rusty