My buddy loves the open road, so he tried that for about 2 months. That was maybe 2015-ish? He said it only looked like he was making money, but budgeting for vehicle upkeep and eventual replacement turned it into a wash, if not a loss, in the long run for him. (I suppose there are different compensation packages out there.)
His wife got into it, too. They wound up driving hotshot deliveries until 2020, when things got really bad. Not as much work, and the work paid less. So he sold their 3 pickups (1 was for parts by then!) and 2 flatbed 5w trailers, and had enough to buy a used (20+ year old) gas moho.
A couple of months after all that, someone who owned several pickups & trailers asked him to drive one of his company rigs, all expenses covered except food, for a flat $1 a mile one way. He agreed, and he told me he was finally making money!!

(That tells us something about costs and hassles of running one's own equipment.) Before long, though, the guy who owned this enterprise cried that he couldn't keep covering the motel costs. My buddy says he keeps chiseling like that every so often.