Backup your sensitive data,
Download ComboFix.exe
A guide and tutorial on using ComboFix
Run ComboFix.exe
Download tfc.exe "Temp File Cleaner by oldtimer"
Run tfc.exe
Boot to safe mode, run maleware bytes and spybot search and destroy
boot to normal mode run a good antivirus (AVG, MSSE, Norton, Mcafee, etc)
If this doesn't clean it reload it.
Good Luck