Agree with all of the comments!!!!
I always recommend picking a coach slide wise, that fits what someone feel is important to them.
For use, we wanted two drivers side slides, but would have bought a coach with the 2nd bedroom slide if we had found a coach that we liked first. We did not want moving kitchen. Because of moving plumbing and more important to us, lost cabinet space at the top of the cabinets. (Though picking up on the comment much depends upon the manufacturer, as many have mastered and reduced greatly the risk of moving plumbing
!). Another factor, is we wanted to have one side with easier access to the basement storage. Even with roll out trays, getting down and under the slides to reach a basement door, and then pull out a roll out tray, can be awkward.
A final consideration for us, a bit contradictory to my comment that we would have taken a coach with the 2nd bedroom slide, is that some of our favorite local campgrounds have 'skinny' sites, so with only one side having slides, it allows us to access some of our favorite sites in these campgrounds.
I also recall our factory tour of Rexhall when we were considering a UFO Gasser coach. They had a 40' DP with two full slides, they call these T-Rex slides as I recall, that the owners had run off the road in New Mexico to avoid a deer. Hit a tree on the front passenger side of the coach. (Gent giving us the tour, said they both were shaken and sore but both walked away from the crash.) The coach was flat bedded to the Rexhall factory for repairs. He said they decided to relook up power to the coach, and see if the slides would still work. Both came out/in, without a problem. Pretty impressive, as the front right corner was damaged pretty bad. Rexhall, Bill Rex, have had many innovation within the RV industry over the years. A few things they do for all of their coaches. Build a welded steel safety gauge around the house. One piece fiberglass roofs and caps (no seems between roof and caps). And others too.
My reason for sharing this, is that here is a large coach with two full wall slides - that structurally is sound.
I believe that most of the higher quality manufactures also build coaches that can handle from 0 up to 4 slides, safely.
One last comment. Remember that each slide adds extra weight, and removes inside storage options. So the number of slides that is right for a person/couple to choose in a coach, has many variables... That being said, if researching for a coach, do research the models you're interested in, and do check in with current owners of those models, for any items (Including potential problems with slides.) that may exist.