I traveled eastbound on 299 from the coast to
I-5 this past October in our 32 foot class A motorhome, pulling our toad. It is scenic drive, but is rather twisty for about the last 10 miles or so before it intersects the interstate. Also there were quite a bit of logging truck traffic. All in all not a bad drive from my point of view. Hwy 20 is good also, been a few years since I was over that way. Enjoy your drive, either way you go.