Hi, I live in the Denver area and I-70 west is my most frequently traveled road.
In Nov. , you could certainly possibly find some snowpack on the higher elevations between Georgetown and Vail. However I-70 is probably C DOT's top priority road and it will be plowed and sanded non stop until the pavement is dry. Also in Nov. it could be sunny and blue skys with 50 to 70* weather.
If you get to Denver and they're having a blizzard up there , you could always stop and spend the night.
2018 Forest River Georgetown F-53
'08 Jeep Wrangler Toad