For reference, I replaced the rear shocks on our 2007 E350 RV chassis without removing tires or jacking up the rig. I did it just sitting on the driveway. It wasn't that difficult given the road clearance.
Just maybe installing airbags would similarly apply.
Our rig came with a 6 ton bottle jack that I have used on the rig for other reasons. It works quite well for the heavy rear end. I later thought I'd like an 8 ton or 12 ton bottle jack, but at the store I learned they are quite heavy to handle, so much that I dropped the idea.
I jack up the front of our rig with a 2-1/4 ton (4500 pound) floor jack that I jack up the front of our motorhome with. Our front axle weighs less than 3300 pounds which offers a reasonable safety margin.