As a general statement a 5th wheel is more labor intensive than setting up a motorhome. That said, the newer 5th wheels are making it easier.
I went through that analysis when I made the deicsion to full time. For my way of life I decided on a MH for ease of doing all this on my own. If I do not need electric or water I don't even have to leave the inside of my coach and be all set up. I also want to move every week or 2. That also weighed in my decision.
If I were a stay in one place for a few months I would have been more swayed to a 5th wheel, as you mentioned.