Dan-
The Ford 2007 Body Builder Layout Book says this about wheels and tires for the F-53 (link
here):
Quote:
WHEELS AND TIRES
1. The 245/70Rx19.5F (18,000 lb, 20,500 lb and
22,000 lb GVWR) and the 225/70Rx19.5F (15,700
lb GVWR) are the only tires approved for the
19.5" steel wheels F-Super Duty Class A Motor
Home Chassis (F53).
2. The 235/80R22.5 XRV LRG Michelin tire (22,000 lb
GVWR) is the only tire approved for the 22.5"
aluminum/steel wheels.
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The placard to the left of the driver's seat should agree with this.
I'm the kind of person who likes to follow the factory specs, if possible (less second-guessing that way). However, you may find you can no longer buy tires this size in Load Range F. For example, a recent Michelin RV tire brochure (link
here) shows just one model tire in 245/70R19.5, the XZE, and it's listed as Load Range H. A search shows a couple other manufacturer's tires this size in Load Range G.